HORDB

ID: hor001760
Uniprot ID: P21259
Protein name: Pol-RFamide-II
Gene name: NA
Organism: Polyorchis penicillatus (Hydromedusa)
Family: FARP (FMRFamide related peptide) family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Polyorchis (genus), Polyorchidae (family), Capitata (suborder), Anthoathecata (order), Hydroidolina (subclass), Hydrozoa (class), Cnidaria (phylum), Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: QWLKGRF
Length: 7(53-59)
Propeptide: MNLITLLVLGVSTCLIYGIEADEKTSSALENEIVEILNGNFKNEKKSIETSDQWLKGRFGREVNQWLKGRFGRELSDQWLKGRFGRELSDQWLKGRFGREVLDQWLKGRFGRDASNQWLKGRFGRELSDQWLKGRFGREGSNQWLKGRFGREASKNDLEKQNGRGDSDQWLKGRFGREARKQLLGGRFGRKDMNQLLAERHGRETSDQWLKGRFGRQLSDQWLKGRFGREVKNDKNNPFRSRYTGDSTQLQRENN
Signal peptide: MNLITLLVLGVSTCLIYGIEA
Modification: T1 Pyrrolidone carboxylic acid;T7 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Has direct action on motoneurons, and effect includes transient inhibition followed by prolonged excitation.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001760_AF2.pdb

hor001760_ESM.pdb

Mass:	104131	Formula:	C45H67N13O9
Absent amino acids:	ACDEHIMNPSTVY	Common amino acids:	FGKLQRW
pI:	11.65	Basic residues:	2
Polar residues:	1	Hydrophobic residues:	3
Hydrophobicity:	-94.29	Boman Index:	-1484
Half-Life / Aliphatic Index:	0.8 hour	Aliphatic Index:	55.71
Instability Index:	194.29	Extinction Coefficient cystines:	5500
Absorbance 280nm:	916.67